Coronavirus Updates: Study stops using Eli Lilly’s antibody treatment for COVID-19 patients due to ‘lack of clinical benefit’

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Coronavirus USA updates: National test-positivity rate above 10%, HHS
Coronavirus USA updates: National test-positivity rate above 10%, HHS

Researchers have stopped testing a combination of remedesivir with one of Eli Lilly and Company’s experimental antibody treatments in hospitalized COVID-19 patients, after an independent review of results found a “lack of clinical benefit.”

The National Institute of Allergy and Infectious Diseases, which is funding the clinical trial, said in a statement Monday that it plans to test other experimental drugs as COVID-19 treatments in the study.

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Eli Lilly and Company said that all other studies of its monoclonal antibody drug, bamlanivimab, will continue, including one in recently diagnosed COVID-19 patients with mild to moderate cases and another in people at risk of infection.

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“While there was insufficient evidence that bamlanivimab improved clinical outcomes when added to other treatments in hospitalized patients with COVID-19, we remain confident based on data from Lilly’s BLAZE-1 study that bamlanivimab monotherapy may prevent progression of disease for those earlier in the course of COVID-19,” Eli Lilly and Company said in a statement Monday.

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Earlier this month, the Indianapolis-based pharmaceutical company asked the U.S. Food and Drug Administration to authorities emergency use of bamlanivimab in non-hospitalized individuals with mild to moderate cases of COVID-19.

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