Space changes how genes are expressed, finds new research

Space changes how genes are expressed, finds new research
Space changes how genes are expressed, finds new research
Space changes how genes are expressed, finds new research
Space changes how genes are expressed, finds new research

Researchers have long known that being in space takes an immense physical toll on the body. But it may also change astronauts’ genes, according to research on NASA’s Scott Kelly and his identical twin brother, Mark Kelly.

The first-of-its-kind opportunity to study the genetic impact of space on the human body came about after astronaut Scott Kelly was chosen to serve aboard the International Space Station from March 2015 to March 2016. His identical twin, Mark Kelly, who is also a former NASA astronaut, remained on Earth.

During the course of NASA’s year-long mission aboard the International Space Station (ISS), researchers from 12 universities analyzed biological samples from both brothers to gauge the genetic shifts that might be taking place.

Space changes how genes are expressed

Preliminary results from the study have revealed that space travel causes an increase in methylation, the process of turning genes on and off, according to NASA.

“Some of the most exciting things that we’ve seen from looking at gene expression in space is that we really see an explosion, like fireworks taking off, as soon as the human body gets into space,” Twins Study principal investigator Chris Mason said in a statement. “With this study, we’ve seen thousands and thousands of genes change how they are turned on and turned off. This happens as soon as an astronaut gets into space, and some of the activity persists temporarily upon return to Earth.”

The most surprising part of the study so far has to do with telomeres. These are essentially caps at the end of DNA that protect our chromosomes. They are thought to be tied to aging, since the length of our telomeres both decrease as we get older and are impacted by such factors as stress, smoking, lack of exercise and a poor diet.

Before the study, scientists speculated that the stress of space living would cause Scott’s telomeres to shrink in comparison to his brother’s. Instead, much to their surprise, the telomeres in Scott’s white blood cells actually grew.

“That is exactly the opposite of what we thought,” Susan Bailey, a radiation biologist at Colorado State University who is working with NASA to study the effect of space on telomeres, told Nature.

Once Scott returned to Earth, his telomeres quickly returned to their pre-mission levels. NASA speculates that the increase may have something to do with the low-calorie diet and strict exercise regimen Scott adhered to while on-board the ISS.

And it changes your gut, too

Other findings of note included a shift in the ratio of two dominant species of gut bacteria in Scott Kelly. While in space, one species dominated over the other. Back on the ground, however, the ratio returned to normal. Researchers performing genome sequencing on the twins also found more than 200,000 RNA molecules that were expressed differently between the twins. Current theories as to why this is happening range from the effects of microgravity to the simple act of eating freeze-dried food for 340 consecutive days.

And then there’s the mystery of DNA methylation, a process that governs chemical modifications to DNA. While in space, Scott’s methylation levels decreased. Over the same time on Earth, Mark’s levels did the complete opposite. According to NASA, such results may indicate “genes that are more sensitive to a changing environment whether on Earth or in space.”

NASA will release final results on the Twins Study, including physiological and psychological findings, in 2018.

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